A new cytotoxic homoisoflavonoid from Dracaena cambodiana

被引：50

作者：

Liu, Jian ^{[1
]}

Mei, Wen-Li ^{[1
]}

Wu, Jiao ^{[1
]}

Zhao, You-Xing ^{[2
]}

Peng, Ming ^{[1
]}

Dai, Hao-Fu ^{[1
]}

机构：

[1] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2009年 / 11卷 / 02期

关键词：

Dracaena cambodiana; Agavaceae; homoisoflavonoid; cytotoxicity; cambodianol;

D O I：

10.1080/10286020802674962

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A new homoisoflavonoid, named cambodianol (1), together with the two known flavanes, (2S)-7,3'-dihydroxy-4'-methoxy-8-methylflavane (2) and (2R)-7,4'-dihydroxy-8-methylflavane (3), were isolated from the stems of Dracaena cambodiana. Their structures were determined based on HR-ESI-MS and spectroscopic techniques (UV, IR, 1D-, and 2D-NMR). Compound 1 exhibited significant cytotoxic activities against K562 and SGC-7901 with the IC50 values of 1.4 and 2.9g/ml, respectively.

引用

页码：192 / 195

页数：4

共 11 条

[1]

Guang dong Institute of Botany, 1977, FLOR HAIN, P155

[2]

Dragon's blood: Botany, chemistry and therapeutic uses [J].

Gupta, Deepika ;

Bleakley, Bruce ;

Gupta, Rajinder K. .

JOURNAL OF ETHNOPHARMACOLOGY, 2008, 115 (03) :361-380

[3]

[何兰 He Lan], 2004, [中草药, Chinese Traditional and Herbal Drugs], V35, P221

[4]

A homo-isoflavonoid and a cytotoxic saponin from Dracaena draco [J].

Hernández, JC ;

León, F ;

Estévez, F ;

Quintana, J ;

Bermejo, J .

CHEMISTRY & BIODIVERSITY, 2006, 3 (01) :62-68

[5]

A xanthone from Garcinia cambogia [J].

Iinuma, M ;

Ito, T ;

Miyake, R ;

Tosa, H ;

Tanaka, T ;

Chelladurai, V .

PHYTOCHEMISTRY, 1998, 47 (06) :1169-1170

[6]

A methylflavan with free radical scavenging properties from Pancratium littorale [J].

Ioset, JR ;

Marston, A ;

Gupta, MP ;

Hostettmann, K .

FITOTERAPIA, 2001, 72 (01) :35-39

[7]

Homoisoflavonoids and xanthones from the tubers of wild and in vitro regenerated Ledebouria graminifolia and cytotoxic activities of some of the homoisoflavonoids [J].

Mutanyatta, J ;

Matapa, BG ;

Shushu, DD ;

Abegaza, BM .

PHYTOCHEMISTRY, 2003, 62 (05) :797-804

[8]

ASSIGNMENT OF QUATERNARY CARBONS IN AROMATIC-COMPOUNDS BY LONG-RANGE HETERONUCLEAR SHIFT CORRELATED 2D-NMR SPECTROSCOPY AND ITS APPLICATION TO ACTEOSIDE [J].

NUMATA, A ;

PETTIT, GR ;

NABAE, M ;

YAMAMOTO, K ;

YAMAMOTO, E ;

MATSUMURA, E ;

KAWANO, T .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1987, 51 (04) :1199-1201

[9]

NUMATA A, 1983, CHEM PHARM BULL, V31, P2146

[10]

Anticancer activity of Hemsleya amabilis extract [J].

Wu, J ;

Wu, YJ ;

Yang, BB .

LIFE SCIENCES, 2002, 71 (18) :2161-2170

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