A novel water-soluble Hantzsch 1,4-dihydropyridine compound that functions in biological processes through NADH regeneration

被引：36

作者：

Sambongi, Y ^{[1
]}

Nitta, H ^{[1
]}

Ichihashi, K ^{[1
]}

Futai, M ^{[1
]}

Ueda, I ^{[1
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, Ibaraki, Osaka 5670047, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 10期

关键词：

D O I：

10.1021/jo025525j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel Hantzsch 1,4-dihydropyridine derivative could function in an organic solvent-free solution, and thus it could function in biological systems. These functions can be accomplished through regeneration of the reduced form of nicotinamine adenine dinucleotide (NADH), an essential compound for living organisms. The results obtained here demonstrate the usefulness of a water-soluble Hantzsch 1,4-dihydropyridine derivative and its wide applicability as a chemical energy source, which drives various biological processes efficiently.

引用

页码：3499 / 3501

页数：3

共 9 条

[1] Turnover number of Escherichia coli F0F1 ATP synthase for ATP synthesis in membrane vesicles [J].

Etzold, C ;

DeckersHebestreit, G ;

Altendorf, K .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 243 (1-2) :336-343

[2]

Hollmann F, 2001, ANGEW CHEM INT EDIT, V40, P169, DOI 10.1002/1521-3773(20010105)40:1<169::AID-ANIE169>3.0.CO

[3]

2-T

[4]

Lo HC, 1999, ANGEW CHEM INT EDIT, V38, P1429, DOI 10.1002/(SICI)1521-3773(19990517)38:10<1429::AID-ANIE1429>3.0.CO

[5]

2-Q

[6]

MORIYAMA Y, 1991, J BIOL CHEM, V266, P22141

[7] ELECTROCHEMICAL PROTON GRADIENT IN INVERTED MEMBRANE-VESICLES FROM ESCHERICHIA-COLI [J].

REENSTRA, WW ;

PATEL, L ;

ROTTENBERG, H ;

KABACK, HR .

BIOCHEMISTRY, 1980, 19 (01) :1-9

[8]

Sund H., 1963, ENZYMES, V7, P25

[9] NICOTINAMIDE COENZYME REGENERATION BY DIHYDROPYRIDINE AND PYRIDINIUM COMPOUNDS [J].

TAYLOR, KE ;

JONES, JB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1976, 98 (18) :5689-5694

← 1 →