Passage of leptin across the blood-testis barrier

被引:67
作者
Banks, WA
McLay, RN
Kastin, AJ
Sarmiento, U
Scully, S
机构
[1] Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, St Louis, MO 63106 USA
[2] St Louis Univ, Sch Med, Dept Internal Med, Div Geriatr, St Louis, MO 63106 USA
[3] Tulane Univ, Sch Med, New Orleans, LA 70146 USA
[4] Amgen Inc, Thousand Oaks, CA 91320 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 1999年 / 276卷 / 06期
关键词
OB protein; obesity; reproduction; gonad; transport;
D O I
10.1152/ajpendo.1999.276.6.E1099
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Leptin is a 17-kDa protein, secreted by fat, that controls adiposity and has been proposed to have numerous effects on reproduction in the mouse. To assess whether the effects of leptin on testicular function are direct, we determined whether leptin can cross the murine blood-testis barrier. Multiple time regression analysis showed that a small amount of blood-borne leptin is able to enter the testis but does so by a nonsaturable process. In addition, no significant expression of leptin receptors was found at the Leydig cells or Sertoli cells of the testis. This compares with the presence of a saturable transport system for leptin at the blood-brain barrier and abundant receptors for leptin at the leptomeninges, neurons, and choroid plexus of the central nervous system (CNS). These results support the hypothesis that the effects of leptin on reproductive function are not mediated at the level of the testis but indirectly, probably through the CNS.
引用
收藏
页码:E1099 / E1104
页数:6
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