A novel serine protease overexpressed in the hair follicles of nude mice

被引:24
作者
Meier, N
Dear, TN
Boehm, T
机构
[1] Max Planck Inst Immunbiol, Dept Dev Immunol, D-79108 Freiburg, Germany
[2] Deutsch Krebsforschungszentrum, D-69120 Heidelberg, Germany
关键词
serine protease; hair follicle; sebaceous gland; nude mouse; overexpression;
D O I
10.1006/bbrc.1999.0600
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have studied changes in gene expression between normal and nude mouse skin. Using the method of representational difference analysis, a cDNA encoding a novel serine protease designated BSSP was cloned. Our results show that in skin this gene is predominantly expressed in the sebaceous gland of the hair follicle and in the distal part of the outer root sheath. Thus, BSSP is the first serine protease known to be expressed in the sebaceous gland. In nude mouse skin, this gene is overexpressed. (C) 1999 Academic Press.
引用
收藏
页码:374 / 378
页数:5
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