From A to Z and back? Multicompartment proteins in the sarcomere

被引：134

作者：

Lange, S

Ehler, E

Gautel, M ^{[1
]}

机构：

[1] Kings Coll London, Randall Div Cell & Mol Biophys, London SE1 1UL, England

[2] Div Cardiovasc, London SE1 1UL, England

[3] ETH Honggerberg, Inst Cell Biol, CH-8093 Zurich, Switzerland

来源：

TRENDS IN CELL BIOLOGY | 2006年 / 16卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.tcb.2005.11.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sarcomeres, the smallest contractile units of striated muscle, are conventionally perceived as the most regular macromolecular assemblies in biology, with precisely assigned localizations for their constituent proteins. However, recent studies have revealed complex multiple locations for several sarcomere proteins within the sarcomere and other cellular compartments such as the nucleus. Several of these proteins appear to relocalize in response to mechanical stimuli. Here, we review the emerging role of these protein networks as dynamic information switchboards that communicate between the contractile machinery and the nucleus to central pathways controlling cell survival, protein breakdown, gene expression and extracellular signaling.

引用

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页码：11 / 18

页数：8

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