Dependence of mesolimbic dopamine transmission on Δ9-tetrahydrocannabinol

被引：65

作者：

Tanda, G

Loddo, P

Di Chiara, G

机构：

[1] Univ Cagliari, Ctr Neuropharmacol, Dept Toxicol, I-09126 Cagliari, Italy

[2] Univ Cagliari, Ctr Neuropharmacol, CNR, I-09126 Cagliari, Italy

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 376卷 / 1-2期

关键词：

Delta(9)-tetrahydrocannabinol; dopamine; microdialysis; nucleus accumbens; rat; SR141716A;

D O I：

10.1016/S0014-2999(99)00384-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rats were administered daily for 8 days with increasing doses (2-12 mg/kg/day) of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and than challenged with different doses of SR141716A, an antagonist of cannabinoid receptors. SR141716A dose dependently reduced dialysate dopamine (DA) in the nucleus accumbens shell and precipitated a physical withdrawal syndrome. No such effects were obtained after administration of SR141716A to saline controls. (C) 1999 Elsevier Science B.V. All rights reserved.

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页码：23 / 26

页数：4

相关论文

共 11 条

[1] CANNABINOID PRECIPITATED WITHDRAWAL BY THE SELECTIVE CANNABINOID RECEPTOR ANTAGONIST, SR 141716A [J].

ACETO, MD ;

SCATES, SM ;

LOWE, JA ;

MARTIN, BR .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 282 (1-3) :R1-R2

[2] Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal [J].

deFonseca, FR ;

Carrera, MRA ;

Navarro, M ;

Koob, GF ;

Weiss, F .

SCIENCE, 1997, 276 (5321) :2050-2054

[3] Mesolimbic dopaminergic decline after cannabinoid withdrawal [J].

Diana, M ;

Melis, M ;

Muntoni, AL ;

Gessa, GL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (17) :10269-10273

[4]

DICHIARA G, 1995, DRUG ALCOHOL DEPEN, V38, P95, DOI 10.1016/0376-8716(95)01118-I

[5] Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra [J].

French, ED ;

Dillon, K ;

Wu, XF .

NEUROREPORT, 1997, 8 (03) :649-652

[6] Drug abuse: Hedonic homeostatic dysregulation [J].

Koob, GF ;

LeMoal, M .

SCIENCE, 1997, 278 (5335) :52-58

[7]

PAXINOS G, 1987, RAT BRAIN STEREOTAXI

[8] SR141716A, A POTENT AND SELECTIVE ANTAGONIST OF THE BRAIN CANNABINOID RECEPTOR [J].

RINALDICARMONA, M ;

BARTH, F ;

HEAULME, M ;

SHIRE, D ;

CALANDRA, B ;

CONGY, C ;

MARTINEZ, S ;

MARUANI, J ;

NELIAT, G ;

CAPUT, D ;

FERRARA, P ;

SOUBRIE, P ;

BRELIERE, JC ;

LEFUR, G .

FEBS LETTERS, 1994, 350 (2-3) :240-244

[9] Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu 1 opioid receptor mechanism [J].

Tanda, G ;

Pontieri, FE ;

DiChiara, G .

SCIENCE, 1997, 276 (5321) :2048-2050

[10] A dopamine μ1 opioid link in the rat ventral tegmentum shared by palatable food (Fonzies) and non-psychostimulant drugs of abuse [J].

Tanda, GL ;

Di Chiara, G .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1998, 10 (03) :1179-1187