A sensitive channel family replete with sense and motion

被引：7

作者：

Minor, DL ^{[1
]}

机构：

[1] Univ Calif San Francisco, Cardiovasc Res Inst, Dept Biochem & Biophys, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, Calif Inst Quantitat Biomed Res, San Francisco, CA 94143 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2006年 / 13卷 / 05期

关键词：

D O I：

10.1038/nsmb0506-388

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new studies demonstrate that transmembrane voltage-sensing domains can act without an obvious pore-forming domain to sense membrane potential changes and make a proton-selective pore.

引用

页码：388 / 390

页数：3

共 15 条

[1] NADPH oxidase [J].

Babior, BM .

CURRENT OPINION IN IMMUNOLOGY, 2004, 16 (01) :42-47

[2] Voltage-gated proton channels and other proton transfer pathways [J].

Decoursey, TE .

PHYSIOLOGICAL REVIEWS, 2003, 83 (02) :475-579

[3] Interface connections of a transmembrane voltage sensor [J].

Freites, JA ;

Tobias, DJ ;

von Heijne, G ;

White, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (42) :15059-15064

[4] Membrane insertion of a potassium-channel voltage sensor [J].

Hessa, T ;

White, SH ;

von Heijne, G .

SCIENCE, 2005, 307 (5714) :1427-1427

[5]

Hille B., 2001, Ion channels of excitable membranes, V3rd

[6] X-ray structure of a voltage-dependent K+ channel [J].

Jiang, YX ;

Lee, A ;

Chen, JY ;

Ruta, V ;

Cadene, M ;

Chait, BT ;

MacKinnon, R .

NATURE, 2003, 423 (6935) :33-41

[7] Voltage sensor of kv1.2: Structural basis of electromechanical coupling [J].

Long, SB ;

Campbell, EB ;

MacKinnon, R .

SCIENCE, 2005, 309 (5736) :903-908

[8] Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor [J].

Murata, Y ;

Iwasaki, H ;

Sasaki, M ;

Inaba, K ;

Okamura, Y .

NATURE, 2005, 435 (7046) :1239-1243

[9]

Petsko GA, 2004, PROTEIN STRUCTURE FU

[10]

RAMSEY IS, 2006, NATURE 0322

← 1 2 →