Protein degradation during aging: the lysosome-, the calpain- and the proteasome-dependent cellular proteolytic systems

被引：45

作者：

Chondrogianni, N

Fragoulis, EG

Gonos, ES

机构：

[1] Natl Hellen Res Fdn, Inst Biol Res & Biotechnol, Athens 11635, Greece

[2] Univ Athens, Sch Biol Sci, Dept Biochem & Mol Biol, Indiana, PA 15701 USA

来源：

BIOGERONTOLOGY | 2002年 / 3卷 / 1-2期

关键词：

aging; calpains; lysosomes; proteasome; protein oxidation; proteolysis; senescence;

D O I：

10.1023/A:1015236203379

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 [法学]; 0303 [社会学]; 100203 [老年医学];

摘要：

Aging is a natural process determined by both genetic and environmental factors. Aging is accompanied by the imbalance of the function of several cellular homeostatic mechanisms, which results, among others, in the accumulation of abnormal (i.e. oxidized, cross-linked, unfolded) proteins. It has been proposed that the increased failure of homeostasis during aging is due to the impaired function of the major cellular proteolytic mechanisms mediated by the lysosome, the calpains and the proteasome. This article will address the issue of the function of these cellular proteolytic systems during aging.

引用

页码：121 / 123

页数：3

共 20 条

[1]

LOW-LEVELS OF CALPAIN ACTIVITY IN CHIROPTERA BRAIN - IMPLICATIONS FOR MECHANISMS OF AGING [J].