The acquisition of purines by trypanosomatids

被引：33

作者：

Cohn, CS

Gottlieb, M

机构：

[1] JOHNS HOPKINS UNIV, DEPT MOL MICROBIOL & IMMUNOL, BALTIMORE, MD 21205 USA

[2] NIAID, DIV MICROBIOL & INFECT DIS, PARASITOL & INT PROGRAMS BRANCH, NIH, BETHESDA, MD 20892 USA

来源：

PARASITOLOGY TODAY | 1997年 / 13卷 / 06期

关键词：

D O I：

10.1016/S0169-4758(97)01059-4

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Parasites of the family Trypanosomatidae have an absolute requirement for purines, yet lack the intracellular machinery to synthesize their own purine ring de novo. As a result, the enzymes devoted to the transport and metabolism of purines are extremely important to the parasite. Here, Claudia Cahn and Michael Gottlieb emphasize the value of understanding purine salvage for the development of trypanocidal drugs, and discuss the putative transporters devoted to purine uptake.

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页码：231 / 235

页数：5

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