Polymorphism in the tumor necrosis factor B gene is associated with Palmoplantar pustulosis

被引：15

作者：

Hashigucci, K

Yokoyama, M

Niizeki, H

Yamasaki, Y

Akiya, K

Tojo, T

Urushibara, T

Yamazaki, Y

Shimizu, H

Nishikawa, T

机构：

[1] Kitasato Inst Hosp, Dept Otolaryngol, Minato Ku, Tokyo 1088642, Japan

[2] Natl Tokyo Med Ctr, Dept Dermatol, Meguro Ku, Tokyo, Japan

[3] Natl Tokyo Med Ctr, Dept Internal Med, Meguro Ku, Tokyo, Japan

[4] Natl Tokyo Med Ctr, Inst Clin Res, Meguro Ku, Tokyo, Japan

[5] Kitasato Univ, Sch Pharmaceut Sci, Ctr Environm Management, Minato Ku, Tokyo 108, Japan

[6] Keio Univ, Sch Med, Dept Otolaryngol, Shinjuku Ku, Tokyo, Japan

[7] Keio Univ, Sch Med, Dept Dermatol, Shinjuku Ku, Tokyo, Japan

来源：

TISSUE ANTIGENS | 1999年 / 54卷 / 03期

关键词：

Palmoplantar pustulosis; TNFB; HLA-DR;

D O I：

10.1034/j.1399-0039.1999.540312.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We investigated the allele and genotype distribution of a polymorphism of the tumor necrosis factor (TNF) B gene and the frequency of HLA-DR9 in 49 patients with Palmoplantar pustulosis (PPP) and 51 healthy controls. We found that the frequency of TNFBB in the PPP patients was significantly higher than that in the controls. Furthermore, the DR9-TNFB8 haplotype was significantly more frequent in the PPP patients (P=0.0045). These results suggest that TNFB2 may confer susceptibility to PPP.

引用

页码：288 / 290

页数：3

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