Effects of a 3-mo consumption of short-chain fructo-oligosaccharides on parameters of colorectal carcinogenesis in patients with or without small or large colorectal adenomas

被引:47
作者
Boutron-Ruault, Marie-Christine
Marteau, Philippe
Lavergne-Slove, Anne
Myara, Anne
Gerhardt, Marie-France
Franchisseur, Claire
Bornet, Francis
机构
[1] Inst Gustave Roussy, EMT, Nutr Hormones & Canc Unit, E3N, F-94805 Villejuif, France
[2] Hop Europeen Georges Pompidou, AP HP, Paris, France
[3] Hop Lariboisiere, Serv Anatomopathol, F-75010 Paris, France
[4] Hop St Joseph, Serv Biochim, F-75674 Paris 14, France
[5] NUTRI HEALTH SA, F-92500 Rueil Malmaison, France
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2005年 / 53卷 / 02期
关键词
D O I
10.1207/s15327914nc5302_5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Intervention studies of colorectal adenoma recurrence have demonstrated the need for surrogate markers of the cancer risk. Short-chain fructo-oligosaccharides (sc-FOS) have protective actions on colon carcinogenesis in animal models. We investigated differences in biological markers between adenoma and adenoma-free subjects, before and after 3 mo of daily intake of 10 g sc-FOS, within a multicenter study. After a full colonoscopy, 3 groups were studied at baseline and after 3 mo: 26 subjects with small colorectal adenoma(s), 18 with large adenoma(s), and 30 with no adenoma. At baseline, the mean fecal butyrate concentration was significantly lower in the adenoma groups than in the adenoma-free group (12.01 +/- 5.08 vs. 17.28 +/- 7.34 mmol/g dry weight) but was significantly increased in that group after 3-mo ingestion of sc-FOS (15.7 +/- 8.0 mmol/g; P = 0.02). In subjects without adenoma, sc-FOS ingestion was associated with a decrease in fecal lithocholic acid (P = 0.02) and an increase in cholic acid (P = 0.02), chenodeoxycholic acid (P = 0.04), total primary bile acids (P = 0.03), and ursodeoxycholic acid (P = 0.05). Fecal pH, blood parameters, and crypt cell proliferation were not significantly modified by sc-FOS ingestion in either group. In subjects with and without adenoma, sc-FOS affects some aspects of the colonic environment, which may be involved in prevention of colorectal neoplasia.
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页码:160 / 168
页数:9
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