Mechanism and Regulation of NLRP3 Inflammasome Activation

被引：3011

作者：

He, Yuan ^{[1
,2
]}

Hara, Hideki ^{[1
,2
]}

Nunez, Gabriel ^{[1
,2
]}

机构：

[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2016年 / 41卷 / 12期

关键词：

NF-KAPPA-B; NALP3; INFLAMMASOME; K+ EFFLUX; GASDERMIN D; INTERLEUKIN-1-BETA SECRETION; DIFFERENTIAL REQUIREMENT; INTRACELLULAR LPS; ENDOTOXIC-SHOCK; DANGER SIGNAL; P2X7; RECEPTOR;

D O I：

10.1016/j.tibs.2016.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Members of the nucleotide-binding domain and leucine-rich repeat (LRR)-containing (NLR) family and the pyrin and HIN domain (PYHIN) family can form multiprotein complexes termed 'inflammasomes'. The biochemical function of inflammasomes is to activate caspase-1, which leads to the maturation of interleukin 1 beta (IL-1D) and IL-18 and the induction of pyroptosis, a form of cell death. Unlike other inflammasomes, the NLRP3 inflammasome can be activated by diverse stimuli. The importance of the NLRP3 inflammasome in immunity and human diseases has been well documented, but the mechanism and regulation of its activation remain unclear. In this review we summarize current understanding of the mechanism and regulation of NLRP3 inflammasome activation as well as recent advances in the noncanonical and alternative inflammasome pathways.

引用

页码：1012 / 1021

页数：10

共 82 条

[1]

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes [J].

Aglietti, Robin A. ;

Estevez, Alberto ;

Gupta, Aaron ;

Ramirez, Monica Gonzalez ;

Liu, Peter S. ;

Kayagaki, Nobuhiko ;

Ciferri, Claudio ;

Dixit, Vishva M. ;

Dueber, Erin C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (28) :7858-7863

[2]

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming [J].

Allam, Ramanjaneyulu ;

Lawlor, Kate E. ;

Yu, Eric Chi-Wang ;

Mildenhall, Alison L. ;

Moujalled, Donia M. ;

Lewis, Rowena S. ;

Ke, Francine ;

Mason, Kylie D. ;

White, Michael J. ;

Stacey, Katryn J. ;

Strasser, Andreas ;

O'Reilly, Lorraine A. ;

Alexander, Warren ;

Kile, Benjamin T. ;

Vaux, David L. ;

Vince, James E. .

EMBO REPORTS, 2014, 15 (09) :982-990

[3]

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome [J].

Bauernfeind, Franz ;

Bartok, Eva ;

Rieger, Anna ;

Franchi, Luigi ;

Nunez, Gabriel ;

Hornung, Veit .

JOURNAL OF IMMUNOLOGY, 2011, 187 (02) :613-617

[4]

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression [J].

Bauernfeind, Franz G. ;

Horvath, Gabor ;

Stutz, Andrea ;

Alnemri, Emad S. ;

MacDonald, Kelly ;

Speert, David ;

Fernandes-Alnemri, Teresa ;

Wu, Jianghong ;

Monks, Brian G. ;

Fitzgerald, Katherine A. ;

Hornung, Veit ;

Latz, Eicke .

JOURNAL OF IMMUNOLOGY, 2009, 183 (02) :787-791

[5]

Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1β and IL-1α from murine macrophages [J].

Brough, D ;

Le Feuvre, RA ;

Wheeler, RD ;

Solovyova, N ;

Hilfiker, S ;

Rothwell, NJ ;

Verkhratsky, A .

JOURNAL OF IMMUNOLOGY, 2003, 170 (06) :3029-3036

[6]

Cholesterol-dependent cytolysins induce rapid release of mature IL-1β from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner [J].

Chu, Jessica ;

Thomas, L. Michael ;

Watkins, Simon C. ;

Franchi, Luigi ;

Nunez, Gabriel ;

Salter, Russell D. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2009, 86 (05) :1227-1238

[7]

Immunological and Inflammatory Functions of the Interleukin-1 Family [J].

Dinarello, Charles A. .

ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :519-550

[8]

Pore-forming activity and structural autoinhibition of the gasdermin family [J].

Ding, Jingjin ;

Wang, Kun ;

Liu, Wang ;

She, Yang ;

Sun, Qi ;

Shi, Jianjin ;

Sun, Hanzi ;

Wang, Da-Cheng ;

Shao, Feng .

NATURE, 2016, 535 (7610) :111-+

[9]

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica [J].

Dostert, Catherine ;

Petrilli, Virginie ;

Van Bruggen, Robin ;

Steele, Chad ;

Mossman, Brooke T. ;

Tschopp, Jurg .

SCIENCE, 2008, 320 (5876) :674-677

[10]

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal [J].

Dostert, Catherine ;

Guarda, Greta ;

Romero, Jackeline F. ;

Menu, Philippe ;

Gross, Olaf ;

Tardivel, Aubry ;

Suva, Mario-Luca ;

Stehle, Jean-Christophe ;

Kopf, Manfred ;

Stamenkovic, Ivan ;

Corradin, Giampietro ;

Tschopp, Jurg .

PLOS ONE, 2009, 4 (08)

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