A crystal milestone: The structure of regulated Src

被引：25

作者：

SupertiFurga, G

Gonfloni, S

机构：

[1] Europ. Molecular Biology Laboratory, D-69117 Heidelberg

来源：

BIOESSAYS | 1997年 / 19卷 / 06期

关键词：

D O I：

10.1002/bies.950190602

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The viral and cellular forms of the Src protein tyrosine kinases take a prototypic role in oncology and signal transduction research, by virtue of being holders of an impressive number of 'firsts'. Our understanding of the biochemistry and physiology of Src has therefore always been used as a reference for our general advancement in the field of protein phosphorylation and growth control. The recent solution of the crystal structure of two members of the Src family((1,2)) represents a milestone in these disciplines and, as usual, provides a general lookout post for developments to come.

引用

页码：447 / 450

页数：4

共 31 条

[1]

Afar DEH, 1996, MOL CELL BIOL, V16, P3465

[2] Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel, p130(Cas)-related protein, Sin [J].