Host resistance to infection - genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes

被引：77

作者：

Qureshi, ST ^{[1
]}

Gros, P

Malo, D

机构：

[1] McGill Univ, Dept Med, Montreal, PQ H3G 1Y6, Canada

[2] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

[3] McGill Univ, Dept Human Genet, Montreal, PQ H3G 1Y6, Canada

[4] Montreal Gen Hosp, Ctr Study Host Resistance, Montreal, PQ H3G 1A4, Canada

来源：

TRENDS IN GENETICS | 1999年 / 15卷 / 08期

关键词：

D O I：

10.1016/S0168-9525(99)01782-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Gram-negative bacterial lipopolysaccharide evokes a protective inflammatory response in the normal host. Through genetic analysis of mutant mice, the gene encoding TOLL-like receptor 4 (Tlr4) was recently identified as a critical component of this host defense mechanism. Tlr4 is a member of an ancient gene family that regulates antimicrobial host defense in plants, invertebrates and mammals.

引用

页码：291 / 294

页数：4

共 24 条

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