PI3K-Akt pathway regulates polycomb group protein and stem cell maintenance

被引：5

作者：

Liu, Yan ^{[1
]}

Yu, Hao ^{[1
]}

Nimer, Stephen D. ^{[2
]}

机构：

[1] Indiana Univ Sch Med, Herman B Wells Ctr Pediat Res, Dept Pediat, Indianapolis, IN USA

[2] Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA

来源：

CELL CYCLE | 2013年 / 12卷 / 02期

关键词：

CANCER; BMI1;

D O I：

10.4161/cc.23379

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：199 / 200

页数：2

共 8 条

[1] Polycomb group proteins: navigators of lineage pathways led astray in cancer [J].

Bracken, Adrian P. ;

Helin, Kristian .

NATURE REVIEWS CANCER, 2009, 9 (11) :773-784

[2] Akt-mediated phsophorylationof EZH2 suppresses methylation of lysine 27 in histone H3 [J].

Cha, TL ;

Zhou, BHP ;

Xia, WY ;

Wu, YD ;

Yang, CC ;

Chen, CT ;

Ping, B ;

Otte, AP ;

Hung, MC .

SCIENCE, 2005, 310 (5746) :306-310

[3] Ezh1 Is Required for Hematopoietic Stem Cell Maintenance and Prevents Senescence-like Cell Cycle Arrest [J].

Hidalgo, Isabel ;

Herrera-Merchan, Antonio ;

Manuel Ligos, Jose ;

Carramolino, Laura ;

Nunez, Javier ;

Martinez, Fernando ;

Dominguez, Orlando ;

Torres, Miguel ;

Gonzalez, Susana .

CELL STEM CELL, 2012, 11 (05) :649-662

[4] CANCER Akt Phosphorylates the Transcriptional Repressor Bmi1 to Block Its Effects on the Tumor-Suppressing Ink4a-Arf Locus [J].

Liu, Yan ;

Liu, Fan ;

Yu, Hao ;

Zhao, Xinyang ;

Sashida, Goro ;

Deblasio, Anthony ;

Harr, Michael ;

She, Qing-Bai ;

Chen, Zhenbang ;

Lin, Hui-Kuan ;

Di Giandomenico, Silvana ;

Elf, Shannon E. ;

Yang, Youyang ;

Miyata, Yasuhiko ;

Huang, Gang ;

Menendez, Silvia ;

Mellinghoff, Ingo K. ;

Rosen, Neal ;

Pandolfi, Pier Paolo ;

Hedvat, Cyrus V. ;

Nimer, Stephen D. .

SCIENCE SIGNALING, 2012, 5 (247)

[5] Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells [J].

Mochizuki-Kashio, Makiko ;

Mishima, Yuta ;

Miyagi, Satoru ;

Negishi, Masamitsu ;

Saraya, Atsunori ;

Konuma, Takaaki ;

Shinga, Jun ;

Koseki, Haruhiko ;

Iwama, Atsushi .

BLOOD, 2011, 118 (25) :6553-6561

[6] Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer [J].

Nacerddine, Karim ;

Beaudry, Jean-Bernard ;

Ginjala, Vasudeva ;

Westerman, Bart ;

Mattiroli, Francesca ;

Song, Ji-Ying ;

van der Poel, Henk ;

Ponz, Olga Balague ;

Pritchard, Colin ;

Cornelissen-Steijger, Paulien ;

Zevenhoven, John ;

Tanger, Ellen ;

Sixma, Titia K. ;

Ganesan, Shridar ;

van Lohuizen, Maarten .

JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (05) :1920-1932

[7] Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation [J].

Orford, Keith W. ;

Scadden, David T. .

NATURE REVIEWS GENETICS, 2008, 9 (02) :115-128

[8] Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells [J].

Yilmaz, Omer H. ;

Valdez, Riccardo ;

Theisen, Brian K. ;

Guo, Wei ;

Ferguson, David O. ;

Wu, Hong ;

Morrison, Sean J. .

NATURE, 2006, 441 (7092) :475-482

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