High pressure activation in the asymmetric Michael addition of chiral imines to alkyl and aryl crotonates

被引：32

作者：

Camara, C

Joseph, D

Dumas, F

d'Angelo, J

Chiaroni, A

机构：

[1] Univ Paris Sud, Ctr Etud Pharmaceut, CNRS, Unite Chim Organ Associee, F-92296 Chatenay Malabry, France

[2] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 08期

关键词：

diastereoselection; enantioselection; imines; Michael reaction; pressure; reactions under;

D O I：

10.1016/S0040-4039(02)00054-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

High pressure-mediated Michael addition of chiral imines derived from 2-methylcyclopentanone, 2-methylcyclohexanone and optically active 1-phenylethylamine, to methyl and phenyl crotonates as investigated, The corresponding adducts ere obtained in fair yields and with a high degree of regio-, diastereo- and enantioselectivity. (C) 2002 Else vier Science Ltd. All rights reserved.

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页码：1445 / 1448

页数：4

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