Creating a False Memory in the Hippocampus

被引：601

作者：

Ramirez, Steve ^{[1
,2
]}

Liu, Xu ^{[1
,2
,3
]}

Lin, Pei-Ann ^{[1
,2
]}

Suh, Junghyup ^{[1
,2
]}

Pignatelli, Michele ^{[1
,2
]}

Redondo, Roger L. ^{[1
,2
,3
]}

Ryan, Tomas J. ^{[1
,2
,3
]}

Tonegawa, Susumu ^{[1
,2
,3
]}

机构：

[1] MIT, Dept Biol, Picower Inst Learning & Memory, RIKEN Massachusetts Inst Technol MIT Ctr Neural C, Cambridge, MA 02139 USA

[2] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

[3] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

来源：

SCIENCE | 2013年 / 341卷 / 6144期

关键词：

LONG-TERM POTENTIATION; FEAR MEMORY; ASSOCIATIVE MEMORY; PATTERN SEPARATION; DENTATE GYRUS; AMYGDALA; RECALL; BRAIN;

D O I：

10.1126/science.1239073

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram-bearing cells in the hippocampus. Dentate gyrus (DG) or CA1 neurons activated by exposure to a particular context were labeled with channelrhodopsin-2. These neurons were later optically reactivated during fear conditioning in a different context. The DG experimental group showed increased freezing in the original context, in which a foot shock was never delivered. The recall of this false memory was context-specific, activated similar downstream regions engaged during natural fear memory recall, and was also capable of driving an active fear response. Our data demonstrate that it is possible to generate an internally represented and behaviorally expressed fear memory via artificial means.

引用

页码：387 / 391

页数：5

共 30 条

[1]

[Anonymous], 1941, Conditioned reflexes and psychiatry

[2]

Bartlett Frederic, 1932, REMEMBERING

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