Atypical chemokine receptors: from silence to sound

被引：35

作者：

Cancellieri, Cinzia ^{[1
,2
]}

Vacchini, Alessandro ^{[1
,2
]}

Locati, Massimo ^{[1
,2
]}

Bonecchi, Raffaella ^{[1
,2
]}

Borroni, Elena M. ^{[1
,2
]}

机构：

[1] Univ Milan, Dept Med Biotechnol & Translat Med, I-20089 Rozzano, Italy

[2] Humanitas Clin & Res Ctr, I-20089 Rozzano, Italy

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2013年 / 41卷

关键词：

beta-arrestin; atypical chemokine receptor; chemokine; G-protein; PROTEIN-COUPLED RECEPTORS; BETA-ARRESTIN; DECOY RECEPTOR; SIGNAL-TRANSDUCTION; CELL-ADHESION; CXCR7; ACTIVATION; D6; ROLES; C5L2;

D O I：

10.1042/BST20120246

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

ACRs (atypical chemokine receptors) were initially referred to as 'silent' receptors on the basis of a lack of signalling and functional activities that are typically observed with conventional chemokine receptors. Although ACRs do not directly induce cell migration, they indirectly control leucocyte recruitment by shaping chemokine gradients in tissues through degradation, transcytosis or local concentration of their cognate ligands. Recent evidence also suggests that these biological activities are supported by G-protein-independent, beta-arrestin-dependent signalling events. In the present article, we review current knowledge on structural and signalling properties of ACRs that are changing our view on this entire class of receptors from silent to endogenous beta-arrestin-biased signalling receptors.

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收藏

页码：231 / 236

页数：6

相关论文

共 47 条

[1]

The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction [J].

Bamberg, Claire E. ;

Mackay, Charles R. ;

Lee, Hyun ;

Zahra, David ;

Jackson, Jenny ;

Lim, Yun Si ;

Whitfeld, Peter L. ;

Craig, Stewart ;

Corsini, Erin ;

Lu, Bao ;

Gerard, Craig ;

Gerard, Norma P. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (10) :7633-7644

[2]

Differential recognition and scavenging of native and truncated macrophage-derived chemokine (macrophage-derived chemokine/CC chemokine ligand 22) by the D6 decoy receptor [J].

Bonecchi, R ;

Locati, M ;

Galliera, E ;

Vulcano, M ;

Sironi, M ;

Fra, AM ;

Gobbi, M ;

Vecchi, A ;

Sozzani, S ;

Haribabu, B ;

Van Damme, J ;

Mantovani, A .

JOURNAL OF IMMUNOLOGY, 2004, 172 (08) :4972-4976

[3]

Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation [J].

Bonecchi, Raffaella ;

Borroni, Elena M. ;

Anselmo, Achille ;

Doni, Andrea ;

Savino, Benedetta ;

Mirolo, Massimiliano ;

Fabbri, Monica ;

Jala, Venkatakrishna R. ;

Haribabu, Bodduluri ;

Mantovani, Alberto ;

Locati, Massimo .

BLOOD, 2008, 112 (03) :493-503

[4]

Chemokine Decoy Receptors: Structure-Function and Biological Properties [J].

Bonecchi, Raffaella ;

Savino, Benedetta ;

Borroni, Elena M. ;

Mantovani, Alberto ;

Locati, Massimo .

CHEMOKINE SYSTEM IN EXPERIMENTAL AND CLINICAL HEMATOLOGY, 2010, 341 :15-36

[5]

Chemokines and chemokine receptors: an overview [J].

Bonecchi, Raffaella ;

Galliera, Emanuela ;

Borroni, Elena M. ;

Corsi, Massimiliano M. ;

Locati, Massimo ;

Mantovani, Alberto .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2009, 14 :540-551

[6]

A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development [J].

Burns, Jennifer M. ;

Summers, Bretton C. ;

Wang, Yu ;

Melikian, Anita ;

Berahovich, Rob ;

Miao, Zhenhua ;

Penfold, Mark E. T. ;

Sunshine, Mary Jean ;

Littman, Dan R. ;

Kuo, Calvin J. ;

Wei, Kevin ;

McMaster, Brian E. ;

Wright, Kim ;

Howard, Maureen C. ;

Schall, Thomas J. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (09) :2201-2213

[7]

The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg74 [J].

Cain, SA ;

Monk, PN .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (09) :7165-7169

[8]

Ubiquitination of CXCR7 Controls Receptor Trafficking [J].

Canals, Meritxell ;

Scholten, Danny J. ;

de Munnik, Sabrina ;

Han, Mitchell K. L. ;

Smit, Martine J. ;

Leurs, Rob .

PLOS ONE, 2012, 7 (03)

[9]

The Duffy antigen/receptor for chemokines exists in an oligomeric form in living cells and functionally antagonizes CCR5 signaling through hetero-oligomerization [J].

Chakera, Aron ;

Seeber, Ruth M. ;

John, Alison E. ;

Eidne, Karin A. ;

Greaves, David R. .

MOLECULAR PHARMACOLOGY, 2008, 73 (05) :1362-1370

[10]

CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, IκB kinase, and nuclear factor-κB and induces cell-cell adhesion and aortic smooth muscle cell proliferation [J].

Chandrasekar, B ;

Bysani, S ;

Mummidi, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (05) :3188-3196

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