Cell biology of the intercalated cell in the kidney

被引：18

作者：

Al-Awqati, Qais ^{[1
,2
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Med, New York, NY 10032 USA

[2] Columbia Univ, Coll Phys & Surg, Dept Physiol & Cellular Biophys, New York, NY 10032 USA

来源：

FEBS LETTERS | 2013年 / 587卷 / 13期

关键词：

Epithelia; Acid-base physiology; Kidney; Intercalated cell; RENAL TUBULAR-ACIDOSIS; TRANSCRIPTION FACTOR FOXI1; PROTEIN-COUPLED RECEPTOR; EPITHELIAL-CELLS; URINARY-BLADDER; TERMINAL DIFFERENTIATION; EXTRACELLULAR-MATRIX; TURTLE BLADDER; ION-TRANSPORT; RICH CELLS;

D O I：

10.1016/j.febslet.2013.05.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The intercalated cell of the collecting tubule of the mammalian kidney is specialized for the transport of H+ and HCO3. They exist in two forms; one specialized for acid secretion and the other secretes HCO3 into the urine. We discovered many years ago that feeding animals an acid diet converts the HCO3 secreting form to an acid secreting type. Here I discuss the molecular basis of this transformation. The conversion of the cell types is mediated by an extracellular matrix protein hensin (also known as DMBT1). However much remains to be identified in the differentiation of these cells. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1911 / 1914

页数：4

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