Hydrolysis of adenine nucleotides in platelets from patients with acute myocardial infarction

被引：14

作者：

Bagatini, Margarete D. ^{[1
]}

Martins, Caroline C. ^{[1
]}

Battisti, Vanessa ^{[1
]}

Spanevello, Roselia M. ^{[1
]}

Gasparetto, Diogo ^{[2
]}

Rosa, Cintia S. ^{[1
]}

Goncalves, Jamile Fabrin ^{[1
]}

Schetinger, Maria Rosa C. ^{[1
]}

dos Santos, Romualdo B. ^{[2
]}

Morsch, Vera Maria ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Programa Posgrad Bioquim Toxicol, Ctr Ciencias Nat & Exatas, Dept Quim, BR-97105900 Santa Maria, RS, Brazil

[2] Univ Fed Santa Maria, Ctr Ciencias Saude, Grp Pesquisa Cardiol, BR-97105900 Santa Maria, RS, Brazil

来源：

CLINICAL BIOCHEMISTRY | 2008年 / 41卷 / 14-15期

关键词：

Acute myocardial infarction; Platelets; Adenine nucleotides; Ischemia;

D O I：

10.1016/j.clinbiochem.2008.07.008

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 [基础医学];

摘要：

Objectives: To investigate the rate of ATP, ADP and AMP hydrolysis on the surface of platelets from acute myocardial infarction (AMI) patients. Design and methods: Twenty-five patients diagnosed with AMI, through clinical criteria, electrocardiographic changes and increase of cardiac biomarkers, as well as 25 healthy patients were selected. The hydrolysis of ATP, ADP and AMP was verified in isolated platelets of these patients. Results: The results demonstrated that an increase in ATP (54%) and ADP (45%) hydrolysis occurred in AMI patients when compared to the control group. The hydrolysis of AMP also increased by 46% in AMI patients probably leading to an enhancement in the adenosine level. Conclusions: Our results suggest an increase in nucleotide hydrolysis in platelets from AMI patients, which could be related to a compensatory organic response to thrombotic events that occur in AMI. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1181 / 1185

页数：5

共 35 条

[1]

Enzymes that hydrolyze adenine nucleotides in platelets from breast cancer patients [J].