Inflammatory pathways and cardiac repair: the affliction of infarction

被引：19

作者：

Knowlton, KU ^{[1
]}

Chien, KR ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, UCSD Salk Program Mol Med, La Jolla, CA 92093 USA

来源：

NATURE MEDICINE | 1999年 / 5卷 / 10期

关键词：

D O I：

10.1038/13441

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent advances have improved our ability to treat the acute symptoms of myocardial infarction, but have done little to prevent the chronic complications that arise afterward. New data suggest that targeting the plasminogen activator and matrix metalloproteinase pathways inhibit adaptive and maladaptive changes that follow myocardial infarction. (pages 1135–1142)

引用

页码：1122 / 1123

页数：2

共 15 条

[1]

BARDOFF, 1999, NAT MED, V5, P320

[2] Development and disease in proteinase-deficient mice: Role of the plasminogen, matrix metalloproteinase and coagulation system [J].

Carmeliet, P ;

Collen, D .

THROMBOSIS RESEARCH, 1998, 91 (06) :255-285

[3] Stress pathways and heart failure [J].

Chien, KR .

CELL, 1999, 98 (05) :555-558

[4]

COLLEN D, 1999, MOL BASIS CARDIOVASC, P537

[5] Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis [J].

Coussens, LM ;

Raymond, WW ;

Bergers, G ;

Laig-Webster, M ;

Behrendtsen, O ;

Werb, Z ;

Caughey, GH ;

Hanahan, D .

GENES & DEVELOPMENT, 1999, 13 (11) :1382-1397

[6] Cardiovascular phenotyping in mice [J].

Doevendans, PA ;

Daemen, MJ ;

de Muinck, ED ;

Smits, JF .

CARDIOVASCULAR RESEARCH, 1998, 39 (01) :34-49

[7] Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure [J].

Heymans, S ;

Luttun, A ;

Nuyens, D ;

Theilmeier, G ;

Creemers, E ;

Moons, L ;

Dyspersin, GD ;

Cleutjens, JPM ;

Shipley, M ;

Angellilo, A ;

Levi, M ;

Nübe, O ;

Baker, A ;

Keshet, E ;

Lupu, F ;

Herbert, JM ;

Smits, JFM ;

Shapiro, SD ;

Baes, M ;

Borgers, M ;

Collen, D ;

Daemen, MJAP ;

Carmeliet, P .

NATURE MEDICINE, 1999, 5 (10) :1135-1142

[8] Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress [J].

Hirota, H ;

Chen, J ;

Betz, UAK ;

Rajewsky, K ;

Gu, Y ;

Ross, J ;

Müller, W ;

Chien, KR .

CELL, 1999, 97 (02) :189-198

[9]

HUNTER JJ, 1999, IN PRESS N ENG J MED

[10] Chronic myocardial infarction in the mouse: cardiac structural and functional changes [J].

Lutgens, E ;

Daemen, MJAP ;

de Muinck, ED ;

Debets, J ;

Leenders, P ;

Smits, JFM .

CARDIOVASCULAR RESEARCH, 1999, 41 (03) :586-593

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