Genetic control of cytokines - Cytokine gene polymorphisms in alopecia areata

被引:16
作者
Cork, MJ
Crane, AM
Duff, GW
机构
[1] University Section of Dermatology, Royal Hallamshire Hospital, Sheffield S10 2JF, Glossop Road
关键词
D O I
10.1016/S0733-8635(05)70393-4
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
It is likely that alopecia areata is a multifactorial disease determined by a combination of genetic and environmental factors. The interaction of susceptibility genes with environmental factors gives rise to the disease phenotype, and then genetic modifying factors determine the extent of the inflammatory response and thereby the clinical outcome. Cytokines regulate the inflammatory response. Polymorphisms in these genes may therefore determine the amount of a cytokine that is produced in response to an environmental trigger such as a bacterial or viral infection.
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页码:671 / &
页数:9
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