Osseointegrated implants in irradiated bone:: A case-controlled study using adjunctive hyperbaric oxygen therapy

被引:118
作者
Granström, G
Tjellström, A
Brånemark, PI
机构
[1] Sahlgrens Univ Hosp, Dept Otolaryngol Head & Neck Surg, S-41345 Gothenburg, Sweden
[2] Gothenburg Univ, Branemark Osseointegrat Ctr, Inst Appl Biotechnol, S-41124 Gothenburg, Sweden
关键词
D O I
10.1016/S0278-2391(99)90059-9
中图分类号
R78 [口腔科学];
学科分类号
1003 [口腔医学];
摘要
Purpose: The current investigation was undertaken to study whether osseointegration of implants in irradiated tissues is subject to a higher failure rate than in nonirradiated tissues. It further aimed to study whether hyperbaric oxygen treatment (HBO) can be used to reduce implant failure. Patients and Methods: Seventy-eight cancer patients who were rehabilitated using osseointegrated implants between 1981 and 1997 were investigated. Three groups of patients were compared: irradiated (A), nonirradiated (B), and irradiated and HBO-treated (C). In addition, 10 irradiated patients who had lost most of their implants received new ones after HBO treatment. These were compared as a case-control group. Results: Implant failures were highest in group A (53.7%). Implant failure was 13.5% in group B and 8.1% in group C, The difference between group A and the other two groups was statistically significant (P =.001 to .0023, Mantell's test). HBO significantly improved implant survival in the case-control group from 34 of 43 implants lost to 5 of 42, lost (P =.0078). Conclusions: Implant insertion in irradiated bone is associated with a higher failure rate. Adjuvant HBO treatment can reduce the failures.
引用
收藏
页码:493 / 499
页数:7
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