Role of membrane traffic in the generation of epithelial cell asymmetry

被引：134

作者：

Apodaca, Gerard ^{[1
,2
]}

Gallo, Luciana I. ^{[1
,2
]}

Bryant, David M. ^{[3
]}

机构：

[1] Univ Pittsburgh, Dept Med, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Dept Cell Biol, Pittsburgh, PA 15261 USA

[3] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94158 USA

来源：

NATURE CELL BIOLOGY | 2012年 / 14卷 / 12期

基金：

美国国家卫生研究院;

关键词：

DARBY CANINE KIDNEY; POLARIZED MDCK CELLS; BASOLATERAL ENDOCYTIC PATHWAYS; CLATHRIN ADAPTER COMPLEXES; ENTEROCYTE-LIKE CELLS; TRANS-GOLGI NETWORK; E-CADHERIN; RECYCLING ENDOSOMES; APICAL MEMBRANE; LUMEN FORMATION;

D O I：

10.1038/ncb2635

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Epithelial cells have an apical basolateral axis of polarity, which is required for epithelial functions including barrier formation, vectorial ion transport and sensory perception. Here we review what is known about the sorting signals, machineries and pathways that maintain this asymmetry, and how polarity proteins interface with membrane-trafficking pathways to generate membrane domains de novo.lt is becoming apparent that membrane traffic does not simply reinforce polarity, but is critical for the generation of cortical epithelial cell asymmetry.

引用

收藏

页码：1235 / 1243

页数：9

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