Ventral and dorsal pathways for language

被引：1105

作者：

Saur, Dorothee ^{[1
,2
]}

Kreher, Bjoern W. ^{[2
,4
]}

Schnell, Susanne ^{[2
,4
]}

Kuemmerer, Dorothee ^{[1
,4
]}

Kellmeyer, Philipp ^{[1
,4
]}

Vry, Magnus-Sebastian ^{[1
,4
]}

Umarova, Roza ^{[1
,4
]}

Musso, Mariacristina ^{[1
,4
]}

Glauche, Volkmar ^{[1
,4
]}

Abel, Stefanie ^{[3
]}

Huber, Walter ^{[3
]}

Rijntjes, Michel ^{[1
]}

Hennig, Juergen ^{[2
,4
]}

Weiller, Cornelius ^{[1
,4
]}

机构：

[1] Univ Med Ctr Freiburg, Dept Neurol, D-79106 Freiburg, Germany

[2] Univ Med Ctr Freiburg, Dept Diagnost Radiol, D-79106 Freiburg, Germany

[3] Univ Aachen, Rhein Westfal TH Aachen, Dept Neurol, Sect Neurolinguist, D-52074 Aachen, Germany

[4] Univ Med Ctr Freiburg, Dept Freiburg Brain Imaging, D-79106 Freiburg, Germany

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 46期

关键词：

DTI; extreme capsule; fMRI; language networks; arcuate fascicle;

D O I：

10.1073/pnas.0805234105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Built on an analogy between the visual and auditory systems, the following dual stream model for language processing was suggested recently: a dorsal stream is involved in mapping sound to articulation, and a ventral stream in mapping sound to meaning. The goal of the study presented here was to test the neuroanatomical basis of this model. Combining functional magnetic resonance imaging (fMRI) with a novel diffusion tensor imaging (DTI)-based tractography method we were able to identify the most probable anatomical pathways connecting brain regions activated during two prototypical language tasks. Sublexical repetition of speech is subserved by a dorsal pathway, connecting the superior temporal lobe and premotor cortices in the frontal lobe via the arcuate and superior longitudinal fascicle. In contrast, higher-level language comprehension is mediated by a ventral pathway connecting the middle temporal lobe and the ventrolateral prefrontal cortex via the extreme capsule. Thus, according to our findings, the function of the dorsal route, traditionally considered to be the major language pathway, is mainly restricted to sensory-motor mapping of sound to articulation, whereas linguistic processing of sound to meaning requires temporofrontal interaction transmitted via the ventral route.

引用

页码：18035 / 18040

页数：6

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