Positive and negative regulation of Src-family membrane kinases by CD45

被引：161

作者：

Thomas, ML ^{[1
]}

Brown, EJ

机构：

[1] Washington Univ, Sch Med, Dept Pathol, Howard Hughes Med Inst, St Louis, MO 63110 USA

[2] Univ Calif San Francisco, Program Microbial Pathogenesis & Host Def, San Francisco, CA 94143 USA

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 09期

关键词：

D O I：

10.1016/S0167-5699(99)01506-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD45 is a protein tyrosine phosphatase that functions to regulate Src-family kinases. However, in some instances CD5 is a positive regulator of kinase activity whereas in others, it is a negative regulator. Here, Matthew Thomas and Eric Brown discuss this paradox and suggest a mechanism by which CD45 can be both a positive and negative regulator of kinase activity simultaneously.

引用

页码：406 / 411

页数：6

共 47 条

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