Endoplasmic reticulum stress in beta cells: Latent mechanism of secondary sulfonylurea failure in type 2 diabetes?

被引：28

作者：

Qian, Lei ^{[1
]}

Zhang, Suhe ^{[2
]}

Xu, Lihong ^{[3
]}

Peng, Yongde ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Endocrine & Metab Dis, Shanghai 200030, Peoples R China

[2] Zhengzhou Univ, Teaching Hosp 2, Dept Endocrine & Metab Dis, Zhengzhou, Peoples R China

[3] Cent Hosp Changning Dist Shanghai, Dept Endocrine & Metab Dis, Shanghai, Peoples R China

来源：

MEDICAL HYPOTHESES | 2008年 / 71卷 / 06期

关键词：

D O I：

10.1016/j.mehy.2008.07.031

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Sulfonylureas, by stimulating beta cell to secrete insulin, are still largely used for treatment of type 2 diabetic patients. More recently concern has been raised with respect to possible adverse effects associated with the use of these agents, like favoring beta cell apoptosis and beta cell exhaustion, which is believed as the reason for high rate secondary sulfonylurea failure. Endoplasmic reticulum (ER) stress often occurred when load of client protein exceed the folding capacity in secretory cell. Here, we hypothesize that overstimulation by chronic use of sulfonylureas could probably leads to ER stress and finally apoptosis in beta cell, which might be the latent mechanism for secondary sulfonylurea failure. (C) 2008 Published by Elsevier Ltd.

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收藏

页码：889 / 891

页数：3

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