Antioxidant action by gold-PAMAM dendrimer nanocomposites

被引：99

作者：

Esumi, K ^{[1
]}

Houdatsu, H

Yoshimura, T

机构：

[1] Tokyo Univ Sci, Dept Appl Chem, Shinjuku Ku, Tokyo 1628601, Japan

[2] Tokyo Univ Sci, Inst Colloid & Interface Sci, Shinjuku Ku, Tokyo 1628601, Japan

来源：

LANGMUIR | 2004年 / 20卷 / 07期

关键词：

D O I：

10.1021/la036299r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold-dendrimer nanocomposites were prepared in the presence of poly(amidoamine) (PAMAM)dendrimer (generation 3, 3.5, 5, and 5.5) via reduction of HAuCl4 with sodium borohydride. The average particle size of the gold nanoparticles was independent of the dendrimer concentration, ranging between 3.0 and 4.3 nm in diameter. The catalytic activities of the gold-dendrimer nanocomposites upon elimination of hydroxyl radicals formed in an H2O2/FeSO4 system were examined using a spin-trapping method. The gold-dendrimer nanocomposites exhibited high catalytic activities which were hardly affected by the concentration and the generation of the dendrimer except PAMAM dendrimer 3.5. The highest activity for the gold-PAMAM dendrimer 3.5 nanocomposites was 85 times that of ascorbic acid.

引用

页码：2536 / 2538

页数：3

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