Analysis of rate of change of IS6110 RFLP patterns of Mycobacterium tuberculosis based on serial patient isolates

被引：124

作者：

de Boer, AS

Borgdorff, MW

de Haas, PEW

Nagelkerke, NJD

van Embden, JDA

van Soolingen, D

机构：

[1] Natl Inst Publ Hlth & Environm, Dept Infect Dis Epidemiol, NL-3720 BA Bilthoven, Netherlands

[2] Natl Inst Publ Hlth & Environm, Diagnost Lab Infect Dis & Perinatal Screening, NL-3720 BA Bilthoven, Netherlands

[3] Natl Inst Publ Hlth & Environm, Bur Informat & Methodol Support, NL-3720 BA Bilthoven, Netherlands

[4] Natl Inst Publ Hlth & Environm, Res Lab Infect Dis, NL-3720 BA Bilthoven, Netherlands

[5] Royal Netherlands TB Assoc, The Hague, Netherlands

[6] Erasmus Med Ctr Univ, Dept Publ Hlth, Rotterdam, Netherlands

[7] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada

来源：

JOURNAL OF INFECTIOUS DISEASES | 1999年 / 180卷 / 04期

关键词：

D O I：

10.1086/314979

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The rate of change of IS6110 restriction fragment length polymorphism (RFLP) patterns of Mycobacterium tuberculosis was determined in serial isolates from 544 patients. In 25 patients (4.6%), the RFLP patterns of the follow-up isolates differed from the initial isolates. Patients with different follow-up strains were less likely to cluster with patients whose strains had indistinguishable RFLP patterns. Changes in RFLP patterns were more common for persons with extrapulmonary disease and for those who had both pulmonary and extrapulmonary isolates. Based on serial isolates spanning for the most part <3 months, the half-life was extrapolated to be 3.2 years (95% confidence interval, 2.1-5.0). The main implication of this study is that the rate of change of IS6110-based RFLP of M. tuberculosis supports the use of IS6110 typing in epidemiologic studies of recent transmission of tuberculosis.

引用

页码：1238 / 1244

页数：7

共 32 条

[1] The IS6110 restriction fragment length polymorphism in particular multidrug-resistant Mycobacterium tuberculosis strains may evolve too fast for reliable use in outbreak investigation [J].