Stepwise large scale synthesis of 3'-sulfo-Lewis(X)-Glc mimetic of the lead anti-inflammatory agent sialyl Lewis(X) in a form suitable for copolymerization with acrylamide has been achieved. The resulting water-soluble copolyacrylamide showed inhibition of binding of both L- and E-selectins in the mu Molar range. Copyright (C) 1996 Elsevier Science Ltd