Combined glycomimetic and multivalent strategies for the design of potent selectin antagonists

被引：37

作者：

Roy, R

Park, WKC

Srivastava, OP

Foxall, C

机构：

[1] UNIV OTTAWA, DEPT CHEM, OTTAWA, ON K1N 6N5, CANADA

[2] GLYCOMED INC, ALAMEDA, CA 94501 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 12期

关键词：

D O I：

10.1016/0960-894X(96)00240-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Stepwise large scale synthesis of 3'-sulfo-Lewis(X)-Glc mimetic of the lead anti-inflammatory agent sialyl Lewis(X) in a form suitable for copolymerization with acrylamide has been achieved. The resulting water-soluble copolyacrylamide showed inhibition of binding of both L- and E-selectins in the mu Molar range. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1399 / 1402

页数：4

共 20 条

[1] STRUCTURE-FUNCTION STUDIES ON SELECTIN CARBOHYDRATE LIGANDS - MODIFICATIONS TO FUCOSE, SIALIC-ACID AND SULFATE AS A SIALIC-ACID REPLACEMENT
BRANDLEY, BK
KISO, M
ABBAS, S
NIKRAD, P
SRIVASATAVA, O
FOXALL, C
ODA, Y
HASEGAWA, A
[J]. GLYCOBIOLOGY, 1993, 3 (06) : 633 - 641
[2] CARLOS TM, 1994, BLOOD, V84, P2068
[3] DASGUPTA F, 1994, EXPERT OPIN INV DRUG, V3, P709
[4] LIGAND RECOGNITION BY E-SELECTIN - SYNTHESIS, INHIBITORY ACTIVITY, AND CONFORMATIONAL-ANALYSIS OF BIVALENT SIALYL-LEWIS-X ANALOGS
DEFREES, SA
KOSCH, W
WAY, W
PAULSON, JC
SABESAN, S
HALCOMB, RL
HUANG, DH
ICHIKAWA, Y
WONG, CH
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (01) : 66 - 79
[5] THE 3 MEMBERS OF THE SELECTIN RECEPTOR FAMILY RECOGNIZE A COMMON CARBOHYDRATE EPITOPE, THE SIALYL LEWIS OLIGOSACCHARIDE
FOXALL, C
WATSON, SR
DOWBENKO, D
FENNIE, C
LASKY, LA
KISO, M
HASEGAWA, A
ASA, D
BRANDLEY, BK
[J]. JOURNAL OF CELL BIOLOGY, 1992, 117 (04) : 895 - 902
[6] IPPOLITO RM, 1836, Patent No. 4909
[7] OLIGOSACCHARIDE RECOGNITION BY SELECTINS - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF MULTIVALENT SIALYL-LEWIS-X LIGANDS
KRETZSCHMAR, G
SPRENGARD, U
KUNZ, H
BARTNIK, E
SCHMIDT, W
TOEPFER, A
HORSCH, B
KRAUSE, M
SEIFFGE, D
[J]. TETRAHEDRON, 1995, 51 (47) : 13015 - 13030
[8] LARSKY LA, 1995, ANNU REV BIOCHEM, V64, P113
[9] Paulson J. C, 1992, ADHESION ITS ROLE IN, P19
[10] THE SELECTINS AND THEIR LIGANDS
ROSEN, SD
BERTOZZI, CR
[J]. CURRENT OPINION IN CELL BIOLOGY, 1994, 6 (05) : 663 - 673

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