Combined glycomimetic and multivalent strategies for the design of potent selectin antagonists

被引:37
作者
Roy, R
Park, WKC
Srivastava, OP
Foxall, C
机构
[1] UNIV OTTAWA, DEPT CHEM, OTTAWA, ON K1N 6N5, CANADA
[2] GLYCOMED INC, ALAMEDA, CA 94501 USA
关键词
D O I
10.1016/0960-894X(96)00240-5
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Stepwise large scale synthesis of 3'-sulfo-Lewis(X)-Glc mimetic of the lead anti-inflammatory agent sialyl Lewis(X) in a form suitable for copolymerization with acrylamide has been achieved. The resulting water-soluble copolyacrylamide showed inhibition of binding of both L- and E-selectins in the mu Molar range. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码:1399 / 1402
页数:4
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