Strategies for dealing with metabolite elucidation in drug discovery and development

被引：100

作者：

Nassar, AEF ^{[1
]}

Talaat, RE ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Dept Drug Metab, Collegeville, PA 19426 USA

来源：

DRUG DISCOVERY TODAY | 2004年 / 9卷 / 07期

关键词：

D O I：

10.1016/S1359-6446(03)03018-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Structural information on metabolites can be a considerable asset for enhancing and streamlining the process of developing new drug candidates. Modern approaches that generate and use metabolite structural information can accelerate the drug discovery and development process by eliminating potentially harmful candidates earlier in the process and improving the safety of new drugs. This review examines the relative merits of current and potential strategies for dealing with metabolite characterization.

引用

页码：317 / 327

页数：11

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