Saponins in tumor therapy

被引：75

作者：

Bachran, Christopher ^{[1
]}

Bachran, Silke

Sutherland, Mark ^{[2
]}

Bachran, Diana ^{[1
]}

Fuchs, Hendrik ^{[1
]}

机构：

[1] Charite, Campus Benjamin Franklin, Zent Inst Lab Med & Pathobiochem, D-12200 Berlin, Germany

[2] Univ Bradford, Inst Canc Therapeut, Bradford BD7 1DP, W Yorkshire, England

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 06期

关键词：

saponin; cancer; tumor therapy; cytotoxicity; triterpenoid; steroid; glycoside;

D O I：

10.2174/138955708784534445

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Saponins are plant glycosides with favorable anti-tumorigenic properties. Several saponins inhibit tumor cell growth by cell cycle arrest and apoptosis with IC50 values of up to 0.2 M. We discuss diverse groups of saponins (dioscins, saikosaponins, julibrosides, soy saponins, ginseng saponins and avicins) investigated in relation to tumor therapy and focus on cellular and systemic mechanisms of tumor cell growth inhibition both in vitro and in vivo. The review also describes saponins in combination with conventional tumor treatment strategies, which result in improved therapeutic success. Some combinations of saponins and anti-tumorigenic drugs induce synergistic effects with potentiated growth inhibition.

引用

页码：575 / 584

页数：10

共 104 条

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