Multidrug resistance: Versatile drug sensors of bacterial cells

被引：43

作者：

Lewis, K ^{[1
]}

机构：

[1] Tufts Univ, Ctr Biotechnol, Medford, MA 02155 USA

来源：

CURRENT BIOLOGY | 1999年 / 9卷 / 11期

关键词：

D O I：

10.1016/S0960-9822(99)80254-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One way that bacteria resist antimicrobial agents involves 'drug sensors', proteins that bind a range of structurally unrelated antimicrobial drugs and induce expression of multidrug resistance pumps. The basis for drug recognition is now becoming clear from the recently determined crystal structure of a drug sensor.

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页码：R403 / R407

页数：5

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