Mild forced treadmill exercise enhances spatial learning in the aged rat

被引：95

作者：

Albeck, DS ^{[1
]}

Sano, K ^{[1
]}

Prewitt, GE ^{[1
]}

Dalton, L ^{[1
]}

机构：

[1] Univ Colorado, Dept Psychol, Denver, CO 80217 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2006年 / 168卷 / 02期

关键词：

Alzheimer's disease; basal forebrain; Morris water maze; NGF; BDNF; neutrophin;

D O I：

10.1016/j.bbr.2005.11.008

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

This study addresses whether or not mild, forced treadmill exercise improves learning and increases neurotrophin levels in the basal forebrain (BF). Neurotrophin deficits in the BF have been implicated in Alzheimer's disease, and physical exercise increases neurotrophins. Aged rats exercised for 7 weeks found the hidden platform faster than controls (F(1, 10) = 14.6, p < 0.05), and swam shorter pathlergths (F(1, 10) = 12.6. p < 0.05), with no difference in swim speed. Neurotrophins did not differ. (c) 2005 Elsevier B.V. All rights reserved.

引用

收藏

页码：345 / 348

页数：4

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