Amino-acid substitutions in acetylcholinesterase 1 involved in insecticide resistance in mosquitoes

被引：32

作者：

Alout, H. ^{[1
]}

Weill, M. ^{[1
]}

机构：

[1] Univ Montpellier 2, CNRS, Inst Sci Evolut, Team Genet Adaptat,Lab Genet & Environm, F-34095 Montpellier 05, France

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2008年 / 175卷 / 1-3期

关键词：

Acetylcholinesterase; Resistance; Insecticide; Mosquito;

D O I：

10.1016/j.cbi.2008.03.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In natural populations of mosquitoes, high level of resistance to carbamates (CX) and organophosphates (OP) is provided by insensitive acetylcholinesterase (AChE1). Different alleles conferring resistance have been identified at the ace 1 locus. They differ from the wildtype by only one amino-acid Substitution. The comparison of the biochemical characteristics of mutated recombinant proteins and AChE1 in resistant mosquito extracts confirmed the role of each substitution in insensitivity. Selection of these different resistant alleles in field populations depends likely on the insecticides used locally. Theoretical modelling studies are initiated to develop novel strategies of mosquito control. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：138 / 141

页数：4

共 17 条

[1]

Alout H, 2007, J MED ENTOMOL, V44, P463, DOI 10.1603/0022-2585(2007)44[463:DASCIR]2.0.CO

[2]

[3] A new amino-acid substitution in acetylcholinesterase 1 confers insecticide resistance to Culex pipiens mosquitoes from Cyprus [J].