Testosterone and Mood in Aging Men

被引：22

作者：

Seidman, Stuart N. ^{[1
,3
]}

Weiser, Mark ^{[2
,3
]}

机构：

[1] West End Med Associates, New York, NY 10024 USA

[2] Tel Aviv Univ, Sackler Fac Med, Dept Psychiat, IL-69978 Ramat Aviv, Israel

[3] Chaim Sheba Med Ctr, Dept Psychiat, IL-52621 Tel Hashomer, Israel

来源：

PSYCHIATRIC CLINICS OF NORTH AMERICA | 2013年 / 36卷 / 01期

关键词：

Testosterone; Partial androgen deficiency of aging male; Hypothalamic-pituitary-gonadal axis; Depression; CONTROLLED-CLINICAL-TRIAL; PLACEBO-CONTROLLED TRIAL; LATE-ONSET HYPOGONADISM; MIDDLE-AGED MEN; SYMPTOMATIC ANDROGEN DEFICIENCY; MAJOR DEPRESSIVE DISORDER; REPLACEMENT THERAPY; REFRACTORY DEPRESSION; OLDER MEN; GEL;

D O I：

10.1016/j.psc.2013.01.007

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Age-associated hypothalamic-pituitary-gonadal (HPG) axis hypofunction, or partial androgen deficiency of the aging male, is thought to be responsible for various age-associated conditions such as reduced muscle and bone mass, mobility limitations, frailty, obesity, sleep apnea, cognitive impairment, sexual dysfunction, and depression. It has been difficult to establish consistent correlations between these symptoms and plasma testosterone levels in middle-aged men, but testosterone replacement does lead to improved muscle strength, bone density, and sexual function. This article focuses on the relationship between testosterone and mood in older men, and the treatment of age-related depression with exogenous testosterone.

引用

页码：177 / +

页数：7

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