Psoriasis, a new challenge for laboratory medicine

被引：7

作者：

Gulletta, Elio ^{[1
]}

Bottoni, Ugo ^{[2
]}

Foti, Daniela P. ^{[1
]}

机构：

[1] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Clin Pathol Unit, I-88100 Catanzaro, Italy

[2] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Dermatol Unit, I-88100 Catanzaro, Italy

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2013年 / 51卷 / 07期

关键词：

analytical biomarkers; IL-17; IL-23; microarray assay; psoriasis; T-reg; SERUM-LEVELS; T-CELLS; GENETICS; MILD; SKIN; IMMUNOPATHOGENESIS; INTERLEUKIN-23; MECHANISMS; BIOMARKERS; PATHWAY;

D O I：

10.1515/cclm-2012-0653

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Psoriasis is an immune-mediated, chronic, inflammatory disease that affects the skin and joints. Because of its high incidence and of its clinical symptoms it has a very strong social impact. In a genetically predisposed individual, the maintenance of the skin barrier integrity is strongly compromised in response to either environmental or self-antigenic insults. A persistent dys-regulation of the skin immune system causes the typical evolutive skin lesions of psoriasis and recurrence of the disease. The most efficient laboratory approach consists of a well-defined evaluation of immune response in order to help diagnosis, to monitor evolution, and to evaluate the effects of individualized therapeutic treatments.

引用

页码：1363 / 1368

页数：6

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