Engineered biosynthesis of novel spinosyns bearing altered deoxyhexose substituents

被引：31

作者：

Gaisser, S

Martin, CJ

Wilkinson, B

Sheridan, RM

Lill, RE

Weston, AJ

Ready, SJ

Waldron, C

Crouse, GD

Leadlay, PF

Staunton, J

机构：

[1] Biotica Technol Ltd, Cambridge CB3 0DJ, England

[2] Dow AgroSci, Indianapolis, IN 46268 USA

[3] Univ Cambridge, Cambridge Ctr Mol Recognit, Cambridge CB2 1GA, England

[4] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

[5] Univ Cambridge, Cambridge Ctr Mol Recognit, Cambridge CB2 1EW, England

[6] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 06期

关键词：

D O I：

10.1039/b200536k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel spinosyns have been prepared by biotransformation, using a genetically engineered strain of Saccharopolyspora erythraea, in which the beta-D-forosamine moiety in glycosidic linkage to the hydroxy group at C17 is replaced by alpha-L-mycarose.

引用

页码：618 / 619

页数：2

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