Roles of the Werner syndrome protein in pathways required for maintenance of genome stability

被引：65

作者：

Brosh, RM ^{[1
]}

Bohr, VA ^{[1
]}

机构：

[1] NIA, Lab Mol Gerontol, NIH, Baltimore, MD 21224 USA

来源：

EXPERIMENTAL GERONTOLOGY | 2002年 / 37卷 / 04期

关键词：

Werner syndrome; helicase; genome stability;

D O I：

10.1016/S0531-5565(01)00227-3

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Werners syndrome is a disease of premature aging where the patients appear much older than their chronological age. The gene codes for a protein that is a helicase and an exonuclease, and recently we have learned about some of its protein interactions. These interactions are being discussed as they shed light on the molecular pathways in which Werner protein participates. Insight into these pathways brings insight into the aging process. Published by Elsevier Science Inc.

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页码：491 / 506

页数：16

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