Persistence of nutritional deficiencies after short-term weight recovery in adolescents with anorexia nervosa

Objectives: To study nutritional abnormalities in adolescent anorexia nervosa and to establish whether certain abnormalities persist after short-term refeeding. Method: Sixty-one patients (10-19 years old) admitted to a reference unit for eating disorders between 1999 and 2000 with a diagnosis of anorexia nervosa were evaluated at admission and at discharge. A range of biochemical, nutritional, and hormonal parameters were determined. Results: At admission, no protein or lipid deficiencies were found, although many patients presented with hormonal abnormalities and red blood cell folate and zinc deficiencies. Hormonal abnormalities reverted significantly (p < .000) after renutrition. There were decreases in erythrocytes and in levels of hemoglobin (p < .000) and folic acid (p < .05). Red blood cell folate and zinc increased but did not reach normal levels. Conclusions: In a large proportion of adolescent anorexic patients, supplementation of folic acid and zinc is recommended although protein or hormonal replacement does not seem to be necessary. (C) 2004 by Wiley Periodicals, Inc.