Porphyrin traps its terminator! Concerted and stepwise porphyrin degradation mechanisms induced by heme-oxygenase and cytochrome P450

被引：59

作者：

Sharma, PK

Kevorkiants, R

de Visser, SR

Kumar, D

Shaik, S ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Dept Organ Chem, IL-91904 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Lise Meitner Minerva Ctr Computat Quantum, IL-91904 Jerusalem, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 09期

关键词：

density functional calculations; enzyme catalysis; enzyme models; heme proteins; oxygenation;

D O I：

10.1002/anie.200352943

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Concerted or stepwise? A homolytic stepwise pathway is taken by the enzyme heme-oxygenase (HO) to degrade the porphyrin ring in heme species. The porphyrin ring assists the enzyme by trapping the hydroxyl radical during the degradation (see scheme). HO is compared to cytochrome P450.

引用

页码：1129 / 1132

页数：4

共 19 条

[1]

[Anonymous], 2000, PORPHYRIN HDB

[2] Kinetic isotope effects on the rate-limiting step of heme oxygenase catalysis indicate concerted proton transfer/heme hydroxylation [J].