Gabapentin associated with aggressive behavior in pediatric patients with seizures

被引：65

作者：

Tallian, KB

Nahata, MC

Lo, W

Tsao, CY

机构：

[1] OHIO STATE UNIV,COLL PHARM,DIV NEUROL,COLUMBUS,OH 43210

[2] OHIO STATE UNIV,COLL MED,DIV NEUROL,COLUMBUS,OH 43210

[3] OHIO STATE UNIV,WEXNER INST PEDIAT RES,DEPT PEDIAT,COLUMBUS,OH 43210

[4] CHILDRENS HOSP,COLUMBUS,OH 43205

来源：

EPILEPSIA | 1996年 / 37卷 / 05期

关键词：

gabapentin; toxicity; aggressive behavior; children;

D O I：

10.1111/j.1528-1157.1996.tb00598.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Gabapentin (GBP) is a new antiepileptic drug (AED) approved for adjunctive treatment of complex partial seizures with or without seizures secondarily generalization in adults. We report 2 children who received GBP for intractable seizures and who developed intolerable aggressive behavior requiring dose reduction or drug discontinuation. Behavioral changes should be recognized as a possible side effect of GBP, especially in mentally retarded children.

引用

页码：501 / 502

页数：2