Improved DNA/emulsion complex stabilized by poly(ethylene glycol) conjugated phospholipid

被引:10
作者
Chesnoy, S
Durand, D
Doucet, J
Stolz, DB
Huang, L [1 ]
机构
[1] Univ Pittsburgh, Sch Pharm, Ctr Pharmacogenet, Pittsburgh, PA 15260 USA
[2] Univ Paris S, LURE, Orsay, France
[3] Univ Pittsburgh, Ctr Biol Imaging, Pittsburgh, PA 15260 USA
关键词
emulsion formulation of DNA; freeze fracture electron microscopy; X-ray diffraction;
D O I
10.1023/A:1012221310136
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:1480 / 1484
页数:5
相关论文
共 18 条
[1]   Monomolecular collapse of plasmid DNA into stable virus-like particles [J].
Blessing, T ;
Remy, JS ;
Behr, JP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) :1427-1431
[2]   In vivo gene delivery to the liver using reconstituted chylomicron remnants as a novel nonviral vector [J].
Hara, T ;
Tan, Y ;
Huang, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (26) :14547-14552
[3]   Stabilization of cationic liposome-plasmid DNA complexes by polyamines and poly(ethylene glycol)-phospholipid conjugates for efficient in vivo gene delivery [J].
Hong, KL ;
Zheng, WW ;
Baker, A ;
Papahadjopoulos, D .
FEBS LETTERS, 1997, 400 (02) :233-237
[4]   Phase diagram, stability, and overcharging of lamellar cationic lipid-DNA self-assembled complexes [J].
Koltover, I ;
Salditt, T ;
Safinya, CR .
BIOPHYSICAL JOURNAL, 1999, 77 (02) :915-924
[5]   An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery [J].
Koltover, I ;
Salditt, T ;
Rädler, JO ;
Safinya, CR .
SCIENCE, 1998, 281 (5373) :78-81
[6]   Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection [J].
Li, S ;
Tseng, WC ;
Stolz, DB ;
Wu, SP ;
Watkins, SC ;
Huang, L .
GENE THERAPY, 1999, 6 (04) :585-594
[7]   Structure and structure-function studies of lipid/plasmid DNA complexes [J].
Lin, AJ ;
Slack, NL ;
Ahmad, A ;
Koltover, I ;
George, CX ;
Samuel, CE ;
Safinya, CR .
JOURNAL OF DRUG TARGETING, 2000, 8 (01) :13-27
[8]   LONG-CIRCULATING EMULSIONS (OIL-IN-WATER) AS CARRIERS FOR LIPOPHILIC DRUGS [J].
LIU, F ;
LIU, D .
PHARMACEUTICAL RESEARCH, 1995, 12 (07) :1060-1064
[9]   Effect of non-ionic surfactants on the formation of DNA/emulsion complexes and emulsion-mediated gene transfer [J].
Liu, F ;
Yang, JP ;
Huang, L ;
Liu, DX .
PHARMACEUTICAL RESEARCH, 1996, 13 (11) :1642-1646
[10]   Submicron lipid emulsions containing amphipathic polyethylene glycol for use as drug-carriers with prolonged circulation time [J].
Lundberg, BB ;
Mortimer, BC ;
Redgrave, TG .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 134 (1-2) :119-127