The Elongation, Termination, and Recycling Phases of Translation in Eukaryotes

被引：323

作者：

Dever, Thomas E. ^{[1
]}

Green, Rachel ^{[2
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Lab Gene Regulat & Dev, NIH, Bethesda, MD 20892 USA

[2] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2012年 / 4卷 / 07期

关键词：

STOP CODON RECOGNITION; MESSENGER-RNA DECAY; NO-GO DECAY; ALLOSTERIC 3-SITE MODEL; AMINOACYL-TRANSFER-RNA; 60S RIBOSOMAL-SUBUNIT; INITIATION-FACTOR; 5A; CHAIN RELEASE FACTOR; SACCHAROMYCES-CEREVISIAE; PROTEIN-SYNTHESIS;

D O I：

10.1101/cshperspect.a013706

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

This work summarizes our current understanding of the elongation and termination/recycling phases of eukaryotic protein synthesis. We focus here on recent advances in the field. In addition to an overview of translation elongation, we discuss unique aspects of eukaryotic translation elongation including eEF1 recycling, eEF2 modification, and eEF3 and eIF5A function. Likewise, we highlight the function of the eukaryotic release factors eRF1 and eRF3 in translation termination, and the functions of ABCE1/Rli1, the Dom34:Hbs1 complex, and Ligatin (eIF2D) in ribosome recycling. Finally, we present some of the key questions in translation elongation, termination, and recycling that remain to be answered.

引用

页数：16

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