Hydrogen peroxide induces protection against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) effects in Escherichia coli

被引:15
作者
Asad, LMBO
Asad, NR
Silva, AB
Felzenszwalb, I
Leitao, AC
机构
[1] FED UNIV RIO DE JANEIRO,INST BIOFIS CARLOS CHAGAS FILHO,LAB RADIOBIOL MOL,BR-21949900 RIO JANEIRO,BRAZIL
[2] UNIV ESTADO RIO DE JANEIRO,INST BIOL,DEPT BIOFIS & BIOMETRIA,BR-20551030 RIO JANEIRO,BRAZIL
来源
MUTATION RESEARCH-DNA REPAIR | 1997年 / 383卷 / 02期
关键词
H2O2; N-methyl-N'-nitro-N-nitrosoguanidine; E-coli; cross-adaptive response;
D O I
10.1016/S0921-8777(96)00053-5
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Cross-adaptive response is defined as the capacity of cells to become resistant to a lethal agent when pretreated with a different lethal substance. In the present paper, the cross-adaptive response between hydrogen peroxide and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was studied in Escherichia coli repair mutants. Our results suggest that high doses of H2O2 induces protection against the lethal effects of MNNG in wild-type strain, ada, ogt, ada-ogt, aidB and alkA mutants. On the other hand, the MNNG induced mutagenesis is reduced by H2O2 pretreatment in wild-type and ogt mutant strains, but not in ada mutant. Furthermore, the protecting effect induced by H2O2 is time dependent: it decreases 15 min after the pretreatment and, after 30 min, is almost abolished. This reduction in the protecting effect is followed by an augmentation in the mutation frequency when MNNG is added 30 min after H2O2 pretreatment. This cross-adaptive response may be due to a modification of the MNNG alkylation pattern in the oxidized DNA.
引用
收藏
页码:137 / 142
页数:6
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