A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival

被引：109

作者：

Rattner, A

Smallwood, PM

Williams, J

Cooke, C

Savchenko, A

Lyubarsky, A

Pugh, EN

Nathans, J ^{[1
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机构：

[1] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Ophthalmol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Microscope Facil, Baltimore, MD 21205 USA

[6] Univ Penn, Sch Med, Dept Ophthalmol, Philadelphia, PA 19104 USA

来源：

NEURON | 2001年 / 32卷 / 05期

关键词：

D O I：

10.1016/S0896-6273(01)00531-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A cadherin family member, prCAD, was identified in retina cDNA by subtractive hybridization and high throughput sequencing. prCAD is expressed only in retinal photoreceptors, and the prCAD protein is localized to the base of the outer segment of both rods and cones. In prCAD(-/-) mice, outer segments are disorganized and fragmented, and there is progressive death of photoreceptor cells. prCAD is unlikely to be involved in protein trafficking between inner and outer segments, since phototransduction proteins appear to be correctly localized and the light responses of both rods and cones are only modestly compromised in prCAD(-/-) mice. These experiments imply a highly specialized cell biological function for prCAD and suggest that localized adhesion activity is essential for outer segment integrity.

引用

页码：775 / 786

页数：12

共 54 条

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