Checkpoints: How to flag up double-strand breaks

被引：24

作者：

Caspari, T ^{[1
]}

Carr, AM ^{[1
]}

机构：

[1] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RR, E Sussex, England

来源：

CURRENT BIOLOGY | 2002年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0960-9822(02)00673-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

How checkpoint pathways recognise double-strand breaks has long been a mystery. Recent studies have found that two distinct checkpoint protein complexes associate independently with chromatin at the sites of DNA damage. Why do two distinct mechanisms recognise strand lesions, and what does this tell us about the checkpoint pathways?

引用

页码：R105 / R107

页数：3

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