NF-κB and Its Regulation on the Immune System

被引：90

作者：

Liang, Yan ^{[1
]}

Zhou, Yang ^{[1
]}

Shen, Pingping ^{[1
]}

机构：

[1] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Dept Biochem, Nanjing 210093, Jiangsu, Peoples R China

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2004年 / 1卷 / 05期

关键词：

NF-kappa B; innate immunity; adaptive immunity; apoptosis;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

NF-kappa B is a transcription factor of eukaryote, five members of whose family in mammals and three in drosophila. Transcription factors of the NF-kappa B family are activated in response to signals that lead to cell growth, differentiation, apoptosis and other events. NF-kappa B takes part in expression of numerous cytokines and adhesion molecules which are critical elements involved in the regulation of immune responses. In this review, we focus on our current understanding of NF-kappa B signal pathway and its role in the innate and adaptive immune responses in which these transcription factors have a key regulatory function. Furthermore we review what is currently known about their effects associated with apoptosis.

引用

页码：343 / 350

页数：8

共 74 条

[1]

5-HT1A-mediated promotion of mitogen-activated T and B cell survival and proliferation is associated with increased translocation of NF-κB to the nucleus [J].