The Implications of Clonal Genome Evolution for Cancer Medicine

被引：281

作者：

Aparicio, Samuel ^{[1
,2
]}

Caldas, Carlos ^{[3
,4
,5
,6
,7
]}

机构：

[1] British Columbia Canc Res Ctr, Dept Mol Oncol, Vancouver, BC V5Z 1L3, Canada

[2] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada

[3] Univ Cambridge, Dept Oncol, Cambridge, England

[4] Canc Res UK Cambridge Inst, Li Ka Shing Ctr, Cambridge, England

[5] Cambridge Univ Hosp Natl Hlth Serv Fdn Trust, Addenbrookes Hosp, Cambridge Breast Unit, Cambridge, England

[6] Cambridge Biomed Res Ctr, Natl Inst Hlth Res, Cambridge, England

[7] Cambridge Expt Canc Med Ctr, Cambridge, England

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2013年 / 368卷 / 09期

关键词：

CHRONIC MYELOGENOUS LEUKEMIA; MUTATIONAL EVOLUTION; ACQUIRED-RESISTANCE; PIK3CA MUTATIONS; KRAS MUTATIONS; GENETIC-BASIS; HETEROGENEITY; CELLS; DNA; IDENTIFICATION;

D O I：

10.1056/NEJMra1204892

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

WITHIN THE NEXT 5 YEARS, INTERNATIONAL EFFORTS MAY CHARACTERize the distribution of clonally dominant somatic mutations (those present in the majority of cells within a cancer) in more than 21,000 cancers of diverse types.(1) A reduction in costs and improvements in technology have placed the sequencing of patients' tumors within practical reach. Preliminary results suggest that full characterization of cancer genomes can be accomplished in a clinically useful time frame.(2,3) Cancer genomics has been the subject of several recent reviews,(4-7) but these have not focused on the implications and opportunities afforded by the realization that cancers are composed of cellular clones. The notion that most cancers are ecosystems of evolving clones has implications for clinical application; we review these, with particular focus on epithelial cancers.

引用

页码：842 / 851

页数：10

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