A study on the chemical constituents of Veratrum nigrum L. processed by rice vinegar

被引：32

作者：

Cong, Yue ^{[1
,2
]}

Wang, Jin-Hui ^{[1
]}

Wang, Rui ^{[3
]}

Zeng, Yi-Mei ^{[1
]}

Liu, Chang-Da ^{[1
]}

Li, Xian ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang, Peoples R China

[2] Henan Univ, Sch Pharm, Inst Tradit Chinese Med, Kaifeng, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2008年 / 10卷 / 07期

关键词：

Veratrum nigrum L; steroid alkaloid; cytotoxicity; 12; beta-hydroxylveratroylzygadenine;

D O I：

10.1080/10286020802133266

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

One new steroid alkaloid, 12 beta-hydroxylveratroylzygadenine (1) and four known compounds, verdine (2), jervine (3), veramarine (4), and veratroylzygadenine (5), have been isolated from the roots and rhizomes of Veratrum nigrum L. processed by rice vinegar. Their structures were established through a combined analysis of physicochemical properties and spectroscopic evidence. The assay results revealed that compounds 1, 4, and 5 exhibited cell toxicity against human HL-60 cells with IC50 values 52.67, 52.90, and 56.51 mu mol/ l, respectively.

引用

页码：616 / 621

页数：6

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